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AKA-114
Higenamine Hydrochloride
Cat. No.
AKA-114
CAS No.
11041-94-4
MF
C16H18ClNO3
MW
307.77
Higenamine hydrochloride is a selective LSD1 inhibitor.
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Technical Data
Description
Storage and Shipping
References
Product Name
Higenamine Hydrochloride
CAS No.
11041-94-4
MF
C16H18ClNO3
MW
307.77
Specification
98%
Research Area
Intermediate
Description
Higenamine hydrochloride is a selective LSD1 inhibitor. Packing: 1kg/bag; 25kg/drum or as request Availability: In Stock
Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Fang Y, et al. Discovery of higenamine as a potent, selective and cellular active natural LSD1 inhibitor for MLL-rearranged leukemia therapy. Bioorganic Chemistry. 2021;109:104723.
[2]. Ha YM, et al. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis. 2012;17(5):463-474.
[3]. Zhu X, et al. Higenamine mitigates interleukin-1β-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K/Akt signaling. Molecular and Cellular Biochemistry. 2021;476(11):3889-3897.
[4]. Deng T, et al. Higenamine Improves Cardiac and Renal Fibrosis in Rats With Cardiorenal Syndrome via ASK1 Signaling Pathway. Journal of Cardiovascular Pharmacology. 2020;75(6):535-544.
[5]. Erasto P, et al. Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model. Natural Products and Bioprospecting. 2018;8(1):63-69.
[6]. Dong H, et al. Higenamine Promotes Osteogenesis Via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice. Journal of Bone and Mineral Research. 2023;38(5):775-791.
[2]. Ha YM, et al. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis. 2012;17(5):463-474.
[3]. Zhu X, et al. Higenamine mitigates interleukin-1β-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K/Akt signaling. Molecular and Cellular Biochemistry. 2021;476(11):3889-3897.
[4]. Deng T, et al. Higenamine Improves Cardiac and Renal Fibrosis in Rats With Cardiorenal Syndrome via ASK1 Signaling Pathway. Journal of Cardiovascular Pharmacology. 2020;75(6):535-544.
[5]. Erasto P, et al. Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model. Natural Products and Bioprospecting. 2018;8(1):63-69.
[6]. Dong H, et al. Higenamine Promotes Osteogenesis Via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice. Journal of Bone and Mineral Research. 2023;38(5):775-791.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
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